Chronic effect on blood pressure of bilateral carotid and vertebral ligation in the rabbit.

ACUTE ISCHEMIA AND HYPERTENSION Hill records that both Poiseuille and Magendie observed acceleration of pulse and a rise of blood pressure in animals following ligation of both carotids, but gives no references. Nawalichin records that clamping the common carotids in anesthetized cats causes a rise in blood pressure; Hill in rabbits and Stewart et al. in dogs, among many subsequent workers, made the same observation. Hedon and Anrep and Starling showed by cross-circulation experiments that lowered perfusion pressure in the cranial circulation would raise blood pressure in the rest of the animal. All these workers interpreted their findings as demonstrating an autoregulatory system in the brain itself, but when Hering" a.nd his co-workers demonstrated the function of the carotid sinus, all these observations became explicable as clue to carotid sinus reflexes.